Mitochondrial dysfunction, iron accumulation, lipid peroxidation, and inflammasome activation in cellular models derived from patients with multiple sclerosis. (PubMed, Aging (Albany NY)) - Feb 7, 2025 - "When challenged against erastin, a ferroptosis inducer, MS fibroblasts showed decreased viability, suggesting increased sensitivity to ferroptosis...These findings were validated in 7 additional patient-derived cell lines. Our findings suggest that the underlying stress phenotype of MS fibroblasts may be disease-specific and recapitulate the main cellular pathological alterations found in the disease such as mitochondrial dysfunction, iron accumulation, lipid peroxidation, inflammasome activation, and pro-inflammatory cytokine production."
Journal • CNS Disorders • Metabolic Disorders • Multiple Sclerosis
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Alejandra López-Cabrera; Ana Romero-González; Anna Di Spirito; David Gómez-Fernandez; Diana Reche-López; José Antonio Sánchez-Alcazar; Jose Manuel Romero-Domínguez; Mónica Álvarez-Córdoba; Paula Cilleros-Holgado; Raquel García-Salas; Rocío Piñero-Perez
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