Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study. (PubMed, Front Mol Biosci) - Feb 4, 2025 - "We have utilized human ovarian cancer cell lines, OVCAR-8 and its adriamycin-selected, multi-drug resistance protein (MDR1)-expressing NCI/ADR-RES, both equally sensitive to ER, to identify metabolic biomarkers of ferroptosis. Our studies identified several potential biomarkers of ER-induced ferroptosis including OPH, taurine, NAD+, NADP+ and glutamate in ovarian cancer cells. Identifying specific metabolic biomarkers that are predictive of whether a cancer is susceptible to ferroptosis will help us devise more successful treatment modalities."
Journal • Metabolic Disorders • Oncology • Ovarian Cancer • Solid Tumor • ABCB1
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Alan K Jarmusch; Birandra K Sinha; Bruce Alex Merrick; Carl D Bortner; Kaylie I Kirkwood-Donelson
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