Dexmedetomidine plays a protective role in sepsis-associated myocardial injury by repressing PRMT5-mediated ferroptosis. (PubMed, Toxicol Res (Camb)) - Feb 4, 2025 - "Dex treatment alleviated LPS-induced cardiomyocyte injury and ferroptosis, while these effects of Dex were reversed by Erastin treatment. Moreover, Dex administration alleviated inflammation, ferroptosis, and myocardial injury in septic mice. Taken together, Dex repressed PMRT5 expression in a m6A-dependent manner, thus lightening LPS-triggered ferroptosis to alleviate cardiomyocyte injury."
Journal • Cardiovascular • Genetic Disorders • Infectious Disease • Inflammation • Obesity • Septic Shock • FTO • METTL3 • PRMT5
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Dan Wang; Jun Wang; Li Yang; Sijian Huang; Xin Wang
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