Humanin reduces nucleus pulposus cells ferroptosis to alleviate intervertebral disc degeneration: An in vitro and in vivo study. (PubMed, J Orthop Translat) - Feb 4, 2025 - "Furthermore, it was ascertained that exogenous HN could trigger endogenous HN expression, impede the JAK2/STAT3 and NF-κB pathways, thereby mitigating erastin-induced ferroptosis in NP cells, contingent upon the upregulation of HSP27 expression...The translational potential of this article: This study highlights the importance and effectiveness of HN in alleviating IDD by inhibiting ferroptosis in NP cells. The addition of exogenous HN may represent a potential therapeutic strategy for treating IDD."
Journal • Preclinical • Back Pain • Fibrosis • Lumbar Back Pain • Musculoskeletal Pain • Pain • HSPB1
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Daxue Zhu; Shijie Chen; Xuewen Kang; Yanhu Li; Zhaoheng Wang
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