Lactate-Fueled Theranostic Nanoplatforms for Enhanced MRI-Guided Ferroptosis Synergistic with Immunotherapy of Hepatocellular Carcinoma. (PubMed, ACS Appl Mater Interfaces) - Feb 4, 2025 - "In this study, a platelet membrane (PM)-engineered nanoparticle loaded with erastin, superparamagnetic iron oxide nanoparticles (SPIO) and lactate oxidase (LOX) (termed PM@ESL NPs) was designed for magnetic resonance imaging (MRI)-guided enhanced ferroptosis-immunotherapy of HCC...Furthermore, the incorporation of SPIO endows PM@ESL NPs with an outstanding MRI-T2 monitoring capability for HCC treatment. In conclusion, this study introduces a pioneering MRI-guided approach that enhances ferroptosis in tumors and synergistically improves immunotherapy."
Journal • Hepatocellular Cancer • Oncology • Solid Tumor
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Baojie DU; Baozhu Yang; Chenying Lu; Fazong Wu; Feng Zhang; Gaofeng Shu; Jiansong Ji; Jiayi Ding; Minjiang Chen; Ronghua Wu; Shiji Fang; Tingting Liao; Weiqian Chen; Xiaoxiao Chen; Zhongwei Zhao
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