High glucose induces podocyte ferroptosis through BAP1/SLC7A11 pathway. (PubMed, Heliyon) - Jan 16, 2025 - "Erastin-induced ferroptosis was sensitized by HG, leading to a significant reduction in glutathione (GSH) levels, increased oxidative stress, and inhibited cystine uptake in podocytes...In BAP1 WT cells, but not in its C91A mutant cells, the transcription of SLC7A11 was downregulated and the level of ferroptosis was increased. HG inhibits cystine uptake in podocytes by promoting the expression of BAP1 and inhibiting H2Aub deubiquitination on SLC7A11, leading to lipid peroxide accumulation and ferroptosis in podocytes."
Journal • Diabetes • Diabetic Nephropathy • Nephrology • Renal Disease • Targeted Protein Degradation • BAP1 • SLC7A11
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Gong Jianguang; He Qiang; Jin Juan; Man Xueli; Ren Peiyao; Sun Wenbo; Zheng Danna
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