Lignans from Schisandra chinensis (Turcz.) Baill ameliorates cognitive impairment in Alzheimer's disease and alleviates ferroptosis by activating the Nrf2/FPN1 signaling pathway and regulating iron levels. (PubMed, J Ethnopharmacol) - Jan 12, 2025 - "The novel discoveries of this study suggest that SCL can suppress ferroptosis in the brains of AD model mice and exerts a partial protective effect against Erastin-induced ferroptosis in HT22 cells, in which the Nrf2/FPN1 signaling pathway plays a crucial role."
Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • ACSL4 • DMRT1 • GPX4 • SLC7A11
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Bing-You Yang; Hai-Xue Kuang; Hong-Yan Yao; Jiu-Jiang Yan; Meng-Meng Li; Qing-Shan Chen; Rui Yang; Shi-Qi Xu; Si-Yi Wang; Wei Guan; Wei Zhao; Xin Meng; Yan Liu; Yi-Kai Jiang; Zhi-Chao Hao
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