Ghrelin Induces Ferroptosis Resistance and M2 Polarization of Microglia to Alleviate Neuroinflammation and Cognitive Impairment in Alzheimer's Disease. (PubMed, J Neuroimmune Pharmacol) - Jan 12, 2025 - "The impact of ghrelin on Aβ1-42-exposed microglia was assessed by coupling with the ferroptosis activator Erastin...Ghrelin induces microglial M2 polarization by inhibiting microglia ferroptosis, thereby alleviating neuroinflammation. Our results indicate that ghrelin may serve as a promising potential agent for treating cognitive impairment in AD."
Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • BMP6 • CD86 • GPX4 • MRC1 • SLC7A11
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Furu Liang; Jing Wu; Junli Zhao; Pu Lu; Xing Liu; Xueyan Wang; Yan Hai; Yaoxue Guo
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