Monitoring of cancer ferroptosis with [18F]hGTS13, a system xc- specific radiotracer. (PubMed, Theranostics) - Jan 12, 2025 - "Furthermore, we evaluated [18F]hGTS13 uptake in a rat model of glioma, both before and after treatment with imidazole ketone erastin (IKE), a pro-ferroptotic inhibitor of system xc- activity...Dynamic PET/CT imaging of C6 glioma-bearing rats with [18F]hGTS13 revealed high and sustained uptake within the intracranial glioma and this uptake was decreased upon pre-treatment with IKE. In summary, [18F]hGTS13 represents a promising tool to distinguish cell types that demonstrate sensitivity or resistance to ferroptosis-inducing therapies that target system xc-, and monitor the engagement of these drugs."
Journal • Brain Cancer • CNS Tumor • Glioblastoma • Glioma • Oncology • Solid Tumor
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Abbas Khojasteh; Abraham Moses; Corinne Beinat; Jody E Hooper; Lawrence D Recht; Madeleine Landry; Marco Herrera-Barrera; Melanie Hayden-Gephart; Monica Granucci; Mustafa Tansel Kendirli; Pierre Cheung; Rim Malek; Scott J Dixon; Syed A Bukhari
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