Downregulation of connexin 32-based gap junctions underlies MSC-sEVs-attenuated ferroptosis in acute-on-chronic liver failure (APASL 2025) - Jan 4, 2025 - Abstract #PP0866; " To establish the ACLF cell model of THLE-2 cell line induced by H2O2 and ACLF mouse model induced by CCL4, collect and identify MSC-sEVs, and added to erastin-induced ACLF hepatocytes... The expression of the Cx32 protein and function of Cx32-GJs in hepatocytes signifcantly enhanced in ACLF, resulting in the accumulation of intracellular ROS and the activation of its downstream ferroptosis signaling pathways, which leads to the spread of ferroptosis in hepatocytes. However, MSC-sEVs can inhibit this process. Table and Figure:Figure 1.Hydrogen peroxide-induced uncoupling of gap junction channels in the ACLF hepatocyte model treated with MSC-sEVs"
Hepatology • Liver Failure • ACSL4
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Zhihui Li 1; Jing Zhang 1; Bingliang Lin 1
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