Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathways. (PubMed, Front Pharmacol) - Dec 31, 2024 - "Interventions included decoctions of AM and SM (for animal experiments) and medicated serum (for cell experiments), along with specific pathway inhibitors such as erastin, FSP1 inhibitor and brequinar. It shows that the protective effect is strongest through GPX4, followed by FSP1, and weakest through DHODH. These findings provide new insights into the therapeutic mechanisms of this combination of botanical drugs."
Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • AIFM2 • DHODH • GPX4
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Can Guo; Jianping Shen; Pengyu Lu; Qiyao Xu; Sujie Zhang; Xindong Wang; Xuan Liu; Zhaoyang Chen
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