NRF2-mediated osteoblast anti-ferroptosis effect promotes induced membrane osteogenesis. (PubMed, Bone) - Dec 29, 2024 - "In vitro, erastin could induce ferroptosis in osteoblasts...In conclusion, in the bone grafting area of the induced membrane, there existed ferroptosis caused by iron overload. Activating the anti-ferroptosis effect of osteoblasts mediated by the NRF2/ARE signaling cascade could promote growth and mineralization of bone grafts within the induced membrane."
Journal • Hematological Disorders • Orthopedics • GPX4 • SLC7A11
|
|
Dawen Yang; Jingtao Zhang; Qishi Zhou; Qunbin Cai; Shuying Li; Shuyuan Li; Songyang Wang; ZhanPeng Zeng
|