Human cytomegalovirus RNA2.7 inhibits ferroptosis by upregulating ferritin and GSH via promoting ZNF395 degradation. (PubMed, PLoS Pathog) - Dec 26, 2024 - "The results further showed that RNA2.7 inhibited ferroptosis via enhancing Ferritin Heavy Chain 1 (FTH1) and Solute Carrier Family 7 Member 11 (SLC7A11) expression in Erastin treated cells without involving other viral components. Pooled Genome-wide CRISPR screening revealed zinc finger protein 395 (ZNF395) as a new regulator repressing the expression of FTH1 and SLC7A11. HCMV RNA2.7 promoted proteasome-mediated degradation of ZNF395 that resulted in upregulation of FTH1 and SLC7A11 to inhibit ferroptosis, therefore maintain survival in host cells and complete replication of virus."
Journal • Cytomegalovirus Infection • Infectious Disease • FTH1 • SLC7A11 • ZFP36L1
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Dan Chen; Jianming Li; Jingxuan Sun; Mingyi Xu; Qiang Ruan; Shan Ruan; Yanping Ma; Ying Qi; Yujing Huang; Zhongyang Liu
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