Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury. (PubMed, Drug Des Devel Ther) - Dec 26, 2024 - "Folic acid (FA)-induced AKI mouse model and erastin/(rsl-3)-induced HK-2 model were constructed to assess the renoprotection of Cur...Mechanistic studies indicated that Cur protected AKI against ferroptosis via inhibition of MAOA thereby regulating 5-hydroxy-L-tryptophan metabolism. Our study for the first time clarified that Cur might acts as a MAOA inhibitor and alleviates ferroptosis in AKI mice, laying a scientific foundation for new insights of clinical therapy on AKI."
Journal • Acute Kidney Injury • Nephrology • Renal Disease
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Fenglin Yang; Hong Zou; Jinwen Zhang; Min Lin; Sijin Zhang; Xi Liu; Yizhi Wang; Yu Zhou; Ziyi Lu
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