PRKAA2 Promotes Tumor Growth and Inhibits Ferroptosis through SLC7A11/GSH/GPX4 Pathway in Non-Small Cell Lung Cancer. (PubMed, Biotechnol Appl Biochem) - Dec 26, 2024 - "The depletion of PRKAA2 enhanced the erastin-induced inhibition effect on cell growth, and notably increased the levels of MDA, ROS, iron, and Fe2+, while decreased GSH level in NSCLC cells...The results discovered that PRKAA2 accelerated the malignant progression, diminished apoptosis and ferroptosis in NSCLC through SLC7A11/GSH/GPX4 pathway. This study provide a novel target in the application of PRKAA2 for NSCLC treatment."
Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • GPX4 • PRKAA2 • SLC7A11
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Erping Xi; Jie Wang; Ke Huang; Mingming Gu; Shaoshan Zeng; Xiangang Kong; Yingming Sun; Yu Zhang; Yuanyu Ding; Zhilian Zhou; Zhiqiang Wei
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