DLBCL cells with ferroptosis morphology can be detected with a deep convolutional neural network. (PubMed, Biomed Pharmacother) - Dec 26, 2024 - "Imidazole ketone erastin (IKE) and auranofin treatment increased blistering cells gradually in dose response manner from 5.4 % to 18.1 % (p < 0.05) and 6.1-50.1 % (p < 0.0001) respectively. We also tested malignant melanoma and breast cancer cell lines to confirm that the blistering phenomena can also be observed in adherent cell lines. We used fluorescence-activated cell sorting to measure the lipid peroxidation associated with ferroptosis and found a significant increase of bodiby-C11oxidized mean compared to DMSO controls for IKE (345 vs 462, p < 0.01) and auranofin (345 vs 686.5, p < 0.05)."
Journal • B Cell Lymphoma • Breast Cancer • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Lymphoma • Melanoma • Non-Hodgkin's Lymphoma • Oncology • Solid Tumor
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Hanna-Riikka Teppo; Hanne Kuitunen; Ilkka Miinalainen; Mikko Chan; Milla E L Kuusisto; Outi Kuittinen; Pyry Kotkaranta; Taina Turpeenniemi-Hujanen; Tero Vuolio
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