Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling. (PubMed, Mol Med Rep) - Dec 24, 2024 - "Conversely, the inhibitory effects of QCT on the apoptosis and inflammatory responses were reversed by the activation of ferroptosis by erastin in IL‑1β‑stimulated chondrocytes...Overall, the present study demonstrated that QCT inhibited the development of OA by suppressing ferroptosis via the activation of the AMPK/Nrf2/Gpx4 signaling pathway. These findings provide novel insights into the regulatory mechanisms of QCT for the treatment of patients with OA."
Journal • Preclinical • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • GPX4 • IL1B
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Genrong Xu; Jiyang Zhao; Liming Chen; Shiyu Dong; Xiaoliang Li
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