Tyrosine phosphatase SHP2 promoted the progression of CRC via modulating the PI3K/BRD4/TFEB signaling induced ferroptosis.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

Tyrosine phosphatase SHP2 promoted the progression of CRC via modulating the PI3K/BRD4/TFEB signaling induced ferroptosis. (PubMed, Discov Oncol) - Dec 18, 2024 - "SHP2 advances CRC progression by modulating TFEB-mediated ferritinophagy, suppressing ROS and ferroptosis. Targeting SHP2 presents a promising therapeutic strategy for CRC."
Journal • Oncology • ACSL4 • BRD4 • EGFR • FTH1 • GPX4 • HIF1A • LAMP2 • MAPK1 • NCOA4 • NOX4 • PI3K • PIK3CA • SQSTM1 • TFEB

http://www.ncbi.nlm.nih.gov/pubmed/39692787

Cheng Jiao; Cheng Zhang; Dihao Wen; Jian Chen; Wei Li

Dec 18, 2024