Overexpression of ELF3 in the PTEN-deficient lung epithelium promotes lung cancer development by inhibiting ferroptosis. (PubMed, Cell Death Dis) - Dec 19, 2024 - "Erastin-mediated inhibition of SCL7A11 induced ferroptosis in cells with ELF3 overexpression and PTEN deficiency and thus inhibited cell colony formation and tumor development...ELF3 and SCL7A11 expression levels were negatively associated with lung cancer patients' survival rates. In summary, ferroptosis induction can effectively attenuate lung tumor development induced by ELF3 overexpression and PTEN downregulation or loss-of-function mutations."
Journal • Lung Cancer • Oncology • Solid Tumor • ELF3 • PTEN
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Artiom Gruzdev; Boyu Wang; Changhui Li; Chen Lian; Di Chen; Fangwei Shao; Francesco J DeMayo; Hua Wang; Huaqiong Huang; Jian Liu; Junming Li; Kehang Zhang; Madhumita Ray; Manyu Xiao; Qian Tang; Qinglin Li; Rong Li; Ruobai Jin; Shiqun Shao; Songsong Li; Taoyu Zhu; Wang Lian; Weiwen Long; Xiaochen Xiang; Xinyan Han; Xinyu Yu; Xuru Jin; Yaping Xu; Ying Lei; Yong Tang; Yufei Liu; Zengzhuang Yuan; Zijin Wang
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