Ilexgenin A Alleviates Myocardial Ferroptosis in Response to Ischemia Reperfusion Injury via the SIRT1 Pathway. (PubMed, Phytother Res) - Dec 19, 2024 - "Additionally, the SIRT1 knockdown by siRNA delivery partially abrogated the beneficial effects of Ilexgenin A on ameliorating mitochondrial damage, and then aggravated erastin-induced ferroptosis in NRCMs. Overall, Our research demonstrated that the inhibition of ferroptosis via the SIRT1 pathway was one of the mechanisms by which Ilexgenin A exerted cardioprotective effect."
Journal • Cardiovascular • Myocardial Ischemia • Reperfusion Injury
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Bin Liu; Bo Deng; Bo Yang; Jing-Zhi Zhang; Li-Ning Yang; Shang-Fei Luo; Shuang-Wei Zhang; Wei-Wei Wu; Xiao-Yu Jue; Yong-Zhen Tan; Yun-Ting Feng; Zhang-Bin Tan
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