High-adhesion ovarian cancer cell resistance to ferroptosis: The activation of NRF2/FSP1 pathway by junctional adhesion molecule JAM3. (PubMed, Free Radic Biol Med) - Dec 21, 2024 - "Knockdowning and blocking JAM3 sensitized cancer cells to ferroptosis inducers RSL3 and erastin, while JAM3 overexpression conferred resistance to these agents. In addition, JAM3 also promoted ovarian cancer cells resistance to chemotherapeutic agent cisplatin in vitro and in vivo by inhibiting ferroptosis...Moreover, JAM3 high expression was associated with poor prognosis in patients with ovarian cancer. Altogether, this study provided novel insights into the molecular mechanisms underlying ferroptosis resistance and identify JAM3 as a potential therapeutic target for combating drug resistance in ovarian cancer."
Journal • CNS Disorders • Oncology • Ovarian Cancer • Psychiatry • Solid Tumor • AIFM2 • JAM3
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Chengsi He; Lei Zhao; Liping Han; Manting Wu; Min Chen; Ning Wang; Qing Tang; Qing Xia; Yibing Chen; Yuan Liao; Yuan Zhou; Zhengzhi Zou; Zheyou Cai
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