MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis. (PubMed, Biol Direct) - Dec 22, 2024 - "A murine model of PE was established, and HTR-8/SVneo cells were induced by Erastin to establish an in vitro cell model...TRIM72 mRNA stability was detected after actinomycin D treatment...TRIM72 bound to ADAM9 and ubiquitinated it for degradation. In conclusion, MLL1 promotes placental trophoblast ferroptosis and aggravates PE symptoms via epigenetic regulation of RBM15/TRIM72/ADAM9 axis."
Journal • Gynecology • Targeted Protein Degradation • ADAM9 • FTH1 • GPX4 • RBM15 • TRIM7 • YTHDF2
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Haining He; Lingling Li; Xiaolan Zhao; Zhenrong Zheng
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