Susceptibility of Mitophagy-Deficient Tumors to Ferroptosis Induction by Relieving the Suppression of Lipid Peroxidation. (PubMed, Adv Sci (Weinh)) - Dec 17, 2024 - "Mitophagy-deficient tumors lack this anti-ferroptotic mechanism, unleashing the generation of lipid peroxidation and potent ferroptotic cell death induced by erastin, RSL3, cysteine deprivation, radiotherapy, and immunotherapy. In summary, patient-derived organoids of colorectal cancer patients for screening ferroptosis-sensitive tumors are established, providing a paradigm for identifying that patient-derived tumors are sensitive to ferroptosis-inducing therapies. This study concludes that mitophagy-deficient tumors are vulnerable to ferroptosis induction, which may lead to the development of new therapeutic strategies for tumors deficient in mitophagy."
Journal • Colorectal Cancer • Oncology • Solid Tumor • ATF4
|
|
Bing-Xin Hu; Chu-Xia Deng; Gong-Kan Feng; Hai-Liang Zhang; Jia-Hong Tang; Jian-Nan Liu; Jing-Hong Chen; Li-Chao Li; Rong Deng; Shan Liu; Xiao-Feng Zhu; Yu-Hong Chen; Zhi-Ming Li; Zhi-Peng Ye
|