Erastin Induces Ferrotposis in Multiple Myeloma Cells through SLC7A11-IRF1-Txn Axis (ASH 2024) - Dec 7, 2024 - "Inhibiting the expression or function of TXN can increase MM cell death through ferroptosis, SCL7A11-IRF1-TXN axis is a new ferroptosis defensive pathway could protect cell from death. TXN is a potential key molecule in regulating ferroptosis and targeting TXN is a novel and promising therapeutic approach to improve the outcome of MM."
Hematological Malignancies • Multiple Myeloma • Oncology • GPX4 • IRF1 • SLC7A11 • TXN
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Jiaxi Liu 1; Rui Liu 2, 3; Ru Zhang 1; Meng Zhai 1; Xuezhu Xu MD 3; Xiaomin Ren 4; Jiyu Miao 1; Aili He PhD MD 3, 5
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