Sarsasapogenin stimulates angiogenesis and osteogenesis coupling to treat estrogen deficiency-induced osteoporosis by activating the GPX4/SLIT3/ROBO1 axis.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

iron dextran - Generic mfg.

Sarsasapogenin stimulates angiogenesis and osteogenesis coupling to treat estrogen deficiency-induced osteoporosis by activating the GPX4/SLIT3/ROBO1 axis. (PubMed, Phytomedicine) - Dec 6, 2024 - "These findings underscore the significance of restoring the GPX4/SLIT3/ROBO1 axis in promoting the coupling of angiogenesis and osteogenesis. SAR mitigates PMOP, in part, by activating the BMSCs-SLIT3/HUVECs-ROBO1 axis, with GPX4 serving as an upstream signaling modulator responsible for SLIT3 production. Our observations provide experimental evidence supporting the clinical application of SAR in the treatment of PMOP."
Journal • Osteoporosis • Rheumatology • GPX4 • SLIT3

http://www.ncbi.nlm.nih.gov/pubmed/39637471

Bingfeng Lin; Fang Wang; Fanxuan Zhang; Nani Wang; Wenlong Xiao; Xuchen Wang

Dec 6, 2024