Fisetin exerts neuroprotective effects in vivo and in vitro by inhibiting ferroptosis and oxidative stress after traumatic brain injury. (PubMed, Front Pharmacol) - Dec 5, 2024 - "Fisetin similarly inhibited the changes in multiple ferroptosis-associated proteins induced by glutamate and erastin, reduced ROS and peroxidation products, and increased the level of antioxidants. In conclusion, fisetin exerts neuroprotective effects in TBI through multiple pathways, thereby alleviating tissue damage and cognitive dysfunction."
Journal • Preclinical • CNS Disorders • Cognitive Disorders • Vascular Neurology
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Haiyi Yang; Mingjie Gong; Qibo Chen; Senling Feng; Shihong Cai; Xixia Liu; Ye Hong; Zhengrong Mei; Zhongwen Yuan
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