Ferroptosis inducer Erastin inhibits proliferation of liver cancer cells in vitro by downregulating ACSL4 (PubMed, Nan Fang Yi Ke Da Xue Xue Bao) - Dec 3, 2024 - "ACSL4 level is significantly overexpressed in liver cancer. Erastin increases MDA contents and down-regulates ACSL4 expression, thereby promoting ferroptosis and inhibiting proliferation of liver cancer cells, and these effects can be reversed by Fer-1."
Journal • Preclinical • Hepatology • Liver Cancer • Oncology • Solid Tumor • ACSL4 • PCNA
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J Tu; P Zhao; S Huang; Y Tu; Y Yang; Z Zhou
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