Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells. (PubMed, J Toxicol Sci) - Dec 2, 2024 - "Cells cultured in FBS containing higher selenium concentrations exhibited elevated GPx4 expression, and were resistant to ferroptosis induced by erastin and RSL3. These findings suggest that the variability of selenium content in different FBS batches can significantly influence the susceptibility of cells to ferroptosis, highlighting the importance of standardizing these factors to enhance the reproducibility of ferroptosis-related experiments."
Journal • Oncology • GPX1 • GPX4
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Atsuya Ichikawa; Eikan Mishima; Hayato Takashima; Junya Ito; Kei Ishida; Kotoko Arisawa; Marcus Conrad; Mayumi Sugawara; Satoru Shiina; Stephanie Siu; Syunsuke Yogiashi; Takashi Toyama; Yinuo Wang; Yoshiro Saito
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