Iberverin Downregulates GPX4 and SLC7A11 to Induce Ferroptotic Cell Death in Hepatocellular Carcinoma Cells. (PubMed, Biomolecules) - Nov 27, 2024 - "In this study, we proved that iberverin can induce intracellular reactive oxygen species (ROS) generation to inhibit cell proliferation and initiate ferroptotic cell death in HCC cells, which can be eradicated by the ferroptosis inhibitor ferrostatin-1 (Fer-1) or deferoxamine mesylate (DFO) and ROS scavenger (GSH or NAC). Significantly, a low dose of iberverin can remarkably increase the sensitivity of HCC cells to ferroptosis induced by canonical ferroptosis inducers RSL3 and imidazole ketone erastin (IKE). This study uncovers a critical function of iberverin in preventing HCC through ferroptosis and provides a promising strategy for HCC treatment either via iberverin alone or in combination with canonical ferroptosis inducers in the future."
Journal • Hepatocellular Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • GPX4 • SLC7A11
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Bolei Dai; Chengchang Gao; Haoying Yang; Liangjie Chen; Linfen Han; Xiaorui Jin; Xueli Bian; Yingping Li
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