MAZ regulates ferroptosis, apoptosis and differentiation of oligodendrocyte precursor cells. (PubMed, Brain Res) - Nov 25, 2024 - "We also evaluated the susceptibility of MAZ-overexpressing OPCs to ferroptosis inducer, erastin, and demonstrated that MAZ-overexpressing OPCs were resistant to erastin-induced ferroptosis...Moreover, we elucidate the mechanism responsible for MAZ's protective effects on OPC death and differentiation, which may be achieved through transcriptional activation of SOX2. Our findings introduced MAZ as a beneficial modulator of OPC survival and differentiation, and it could serve as a potential therapeutic target for demyelination diseases."
Journal • Solid Tumor • MAZ • MYC • SOX2
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Fangkun Jing; Haitao Huang; Jingyu Dong; Quancai Wang; Yanfeng Li; Yangxi Xu
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