Engineered nanoplatform mediated gas therapy enhanced ferroptosis for tumor therapy in vivo. (PubMed, Bioact Mater) - Nov 19, 2024 - "Additionally, Erastin depletes GSH by inhibiting the cystine/glutamate antiporter system, reducing cystine uptake and impairing GPX4, while also increasing intracellular H2O2 levels by activating NOX4 protein expression...Furthermore, this nanoplatform significantly inhibited tumor cell growth and extended the survival time of tumor-bearing mice in vivo. This engineered nanoplatform, which enhances ferroptosis through gas therapy, shows significant promise for ferroptosis-based cancer therapy and offers potential strategies for clinical tumor treatment."
Journal • Preclinical • Oncology • GPX4 • NOX4
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Kaiyong Cai; Ke Li; Kun Xu; Liangshuai Zhang; Meijun Tan; Peng Liu; Xuan Li; Ye He; Yulan Mao; Yulu Yang; Zhong Luo
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