Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc. (PubMed, Spine J) - Nov 16, 2024 - "Nutrient deprivation is a major contributor to intervertebral disc degeneration. Our in vitro and ex vivo study showed that low dose of erastin may suppress nutrient deprivation induced cell death in IVD degeneration. Although it was not validated in vivo model due to lack of in vivo nutrient deprivation induced IVD degeneration model currently, this study may still provide a potential therapeutic option for IVD degeneration, which of cause need further validation."
Journal • SLC7A11 • TFEB
|
|
Aimin Wu; Jie Jin; Naifeng Tian; Xiangyang Wang; Xiaolei Zhang; Ximiao Chen; Yan Wu; Yaosen Wu; Yifei Zhou; Yu Chen; Zengjie Zhang; Zhenxuan Shao
|