Didang Tang alleviates neuronal ferroptosis after intracerebral hemorrhage by modulating the PERK/eIF2α/ATF4/CHOP/GPX4 signaling pathway. (PubMed, Front Pharmacol) - Nov 15, 2024 - "An ICH rat model and hemin and erastin-induced PC12 cell ferroptosis models were developed to investigate DDT's neuroprotective mechanisms...DDT alleviates neuronal ferroptosis after ICH by modulating the PERK/eIF2α/ATF4/CHOP/GPX4 signaling pathway. Overall, this study provides novel insights into DDT's protective mechanisms against ICH-induced neuronal injury by modulating ferroptosis and ERS pathways, underscoring its potential as an effective therapeutic strategy."
Journal • Cerebral Hemorrhage • Hematological Disorders • ATF4 • GPX4 • HSPA5 • SLC7A11
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Dongmei Zhang; Hanying Xu; Jian Wang; Jing Lu; Li Li; Liwei Sun; Peng Xu; Xiaolei Tang; Ying Zhang
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