1α,25-hydroxyvitamin D3 alleviated rotavirus infection induced ferroptosis in IPEC-J2 cells by regulating the ATF3-SLC7A11-GPX4 axis. (PubMed, Int J Biol Macromol) - Nov 15, 2024 - "Present study shows that RV infection or erastin treatment induces IPEC-J2 cell death, which results in mitochondrial shrinkage, decreased mitochondrial membrane potential (MMP) and glutathione (GSH) content, increased MMP, intracellular Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) contents. Meanwhile, ferrostatin-1 (Fer-1), liproxstatin-1 (Lip-1), and deferoxamine (DFO) treatment can effectively reverse the increase of intracellular Fe2+, ROS and MDA levels induced by RV infection...1,25D3 treatment significantly eliminates RV induced ferroptosis via ATF3-SLC7A11-GPX4 axis. Therefore, our results reveals that RV infection induces ferroptosis in IPEC-J2 cell and 1,25D3 alleviates RV induced ferroptosis by regulating the ATF3-SLC7A11-GPX4 axis."
Journal • Infectious Disease • Rotavirus Infections • ANXA2 • ATF3 • GPX4 • SLC7A11
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Lei Chen; Lei Song; Li Zhu; Lili Niu; Linyuan Shen; Mailin Gan; Pan Shang; Qingyuan Lan; Shijie Hu; Xiaoxiao Zhu; Yan Wang; Ye Zhao; Ziang Wei
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