LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma. (PubMed, Cell Death Dis) - Nov 14, 2024 - "Together, our study identified HBX's role in inhibiting MALAT1 expression, promoting SFPQ-mediated splicing of SLC7A11 pre-mRNA, and reducing the GCB-type DLBCL sensitivity to Erastin-induced ferroptosis. Combined with the recent studies that ferroptosis may be involved in the occurrence and development of DLBCL, these findings explain our clinical data analysis that DLBCL patients with low expression of MALAT1 have poorer prognosis and shorter overall survival, and provide a valuable therapeutic target for the HBV-infected GCB-type DLBCL patients."
Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Hepatitis B • Hepatology • Infectious Disease • Lung Adenocarcinoma • Lung Cancer • Lymphoma • Non Small Cell Lung Cancer • Non-Hodgkin's Lymphoma • Oncology • Solid Tumor • MALAT1 • SLC7A11
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Ailing Tan; Jianguo Li; Jie Chen; Jiuhong Kang; Qiaoyi Sun; Xiaofei Bai; Xu Xu; Xudong Guo; Xuecong Guo; Yinghui Huang; Yisha Jia
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