FERROPTOSIS INDUCTION: A BIOCHEMICAL VULNERABILITY OF SOFT TISSUE SARCOMAS (CTOS 2024) - Nov 9, 2024 - Abstract #P 09; "It is examined whether soft tissue sarcomas in general, because of their mesenchymal origin, may also exhibit an increased sensitivity for ferroptosis induction. A variety of sarcoma (n=9) and carcinoma (n=6) cell lines, representing distinct tumor types, were exposed to ferroptosis-inducing compounds like the GPX4 inhibitor ML210 and the system Xc- inhibitor erastin after which in vitro cytotoxicity assays were performed. This study clearly highlights a biochemical vulnerability of soft tissue sarcomas namely the sensitivity to ferroptosis induction which could be exploited to develop more effective therapeutic strategies for this class of rare mesenchymal tumors. The underlying molecular causes for the observed increased vulnerability for ferroptosis are not yet completely understood and warrant further investigations."
Oncology • Sarcoma • Soft Tissue Sarcoma • Solid Tumor • ACSL4 • GPX4 • NQO1
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Erik A.C Wiemer, PhD (he/him/his)
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