Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1/GPX4 signaling pathway. (PubMed, Toxicol Appl Pharmacol) - Oct 31, 2024 - "In this study, LCR and ferrostatin-1 alleviated, but erastin aggravated caerulein (CAE) exposure-induced cytotoxicity and reduction of cell viability in AR42J cells...Furthermore, functional rescue experiments manifested that knockdown of SIRT1 partially negated the inhibitory action of LCR against CAE-induced apoptosis, inflammation, and ferroptosis in AR42J cells. Overall, LCR mitigates apoptosis, inflammation, and ferroptosis in CAE-exposed AR42J cells, which is related to the activation of the SIRT1/GPX4 signaling pathway."
Journal • Hepatology • Inflammation • Pancreatitis • GPX4
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Bangjiang Fang; Chong Zhang; Chunyan Li; Dahuan Li; Guoxiu Zhang; Simin Jiang; Tianzhong Wang; Zhao Zhu
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