(-)-Epicatechin regulates endoplasmic reticulum stress and promotes ferroptosis in lung cancer cells via the PERK/eIF2α/ATF4 signaling pathway.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

(-)-Epicatechin regulates endoplasmic reticulum stress and promotes ferroptosis in lung cancer cells via the PERK/eIF2α/ATF4 signaling pathway. (PubMed, PLoS One) - Oct 31, 2024 - "EC therapy activates the PERK-eIF2α-ATF4 signaling pathway to increase ER stress, thereby promoting ferroptosis in lung cancer cells and inhibiting the occurrence and development of lung cancer. Our research suggests that EC may become a drug candidate for treating lung cancer."
Journal • Lung Cancer • Oncology • Solid Tumor • ATF4

http://www.ncbi.nlm.nih.gov/pubmed/39480832

Anao Wu; Jianhua Ji; Liqiong Zhang; Meifang Huang; Peiwan Liu; Wenhui Li; Wensheng Huang; Yingyu Yang; Yunkui Yang; Zengbo Lv; Zhijun Zhang

Oct 31, 2024