Menaquinone-4 Alleviates Sepsis-Associated Acute Lung Injury via Activating SIRT3-p53/SLC7A11 Pathway. (PubMed, J Inflamm Res) - Oct 29, 2024 - "Cecal ligation and puncture (CLP) surgery is a commonly used method to induce sepsis in C57BL/6N wild-type mice, and the mice were administered MK-4 at a dosage of 200 mg/kg/day and 3-TYP at 5 mg/kg/day via intraperitoneal injection for 3 days, or erastin (5 mg/kg) 0.5 hours before CLP surgery...These findings indicate that MK-4 is a promising novel therapeutic agent for treating SI-ALI and possibly sepsis. These experiments revealed that MK-4 acts as a ferroptosis suppressor, increasing the expression of Sirt3, inhibiting the p53/SLC7A11 signalling pathway, and reducing oxidative stress and inflammatory responses, thereby exerting a protective effect against ALI in sepsis."
Journal • Acute Lung Injury • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases • Septic Shock • GPX4 • SIRT3 • SLC7A11
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Guo-Qiang Zhang; Jie Chen; Nan Gao; Tian-Peng Hu; Xiao-Yu Liu; Yu Wang
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