Study on the Synergistic Mechanism of Photodynamic Therapy Combined With Ferroptosis Inducer to Induce Ferroptosis in Cholangiocarcinoma.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

Lenvima (lenvatinib) - Eisai, Merck (MSD)

Study on the Synergistic Mechanism of Photodynamic Therapy Combined With Ferroptosis Inducer to Induce Ferroptosis in Cholangiocarcinoma. (PubMed, Lasers Surg Med) - Oct 29, 2024 - "Our findings suggest that Erastin or Lenvatinib can enhance the induction of ferroptosis in cholangiocarcinoma cells by photodynamic therapy by increasing intracellular ROS and inhibiting intracellular antioxidant pathways."
Journal • Biliary Cancer • Cholangiocarcinoma • Gastrointestinal Cancer • Oncology • Solid Tumor • AIFM2 • GPX4 • SLC7A11

http://www.ncbi.nlm.nih.gov/pubmed/39468974

An Jiang; Qifan Liu; Shiqi An; Sifan Dong; Xujia Wang; Yongmei Hu

Oct 29, 2024