Network pharmacology, molecular docking and experimental study on the mechanism of Curcumin's anti-ferroptosis in melanocytes. (PubMed, Biochem Biophys Res Commun) - Oct 27, 2024 - "Then, the effects of Cur on Erastin-induced ferroptosis were investigated in melanocytes induced by Erastin in vitro...Interestingly, pretreatment with ML385, a selective Nrf2 inhibitor, counteracted anti-ferroptosis effects induced by Cur treatment. Taken together, these results demonstrate that Cur inhibits ferroptosis by regulating the Nrf2/HO-1 pathway to protect melanocytes."
Journal • Dermatology • Immunology • Vitiligo • ACSL4 • GPX4 • HMOX1 • TFRC
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Chuan-Jian Yuan; Jin-Xiang Yuan; Jing Luo; Jun-Kai Huang; Jun-Ling Zhang; Lyu-Ye Liu; Si-Jia He
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