Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferroptosis induction. (PubMed, Nat Commun) - Oct 18, 2024 - "Moreover, SAM supplementation synergizes with Imidazole Ketone Erastin in a tumor growth suppression mouse model. Inhibiting the enzyme that converts methionine to SAM protects heart tissue from Doxorubicin-induced and ferroptosis-driven cardiomyopathy. This study broadens our understanding about the intersection of amino acid metabolism and ferroptosis regulation, providing insight into the underlying mechanisms and suggesting the methionine-SAM axis is a promising therapeutic strategy to treat ferroptosis-related diseases."
Journal • Cardiomyopathy • Cardiovascular • Oncology
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Chaoyi Xia; Fengqi Hao; Jianlan Du; Kejian Dong; Miaomiao Tian; Min Wei; Pinghui Peng; Wanting Peng; Wenxia Zhang; Xin Jin; Xiyue Xing; Xueqing Ba; Yang Wang; Yunpeng Feng; Zhexuan Zhao
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