Macrophage Piezo1 exacerbates cardiac dysfunction through inhibiting clearance of apoptotic cardiomyocytes after myocardial infarction (AHA 2024) - Oct 18, 2024 - Abstract #BCVS13; Pres time: Nov 16, 2024; 02:00 PM - 03:00 PM; Location: Best of Specialty Conferences Posters; "The small interfering RNA (siRNA) mediated SLC7A11 knockdown or erastin-mediated SLC7A11 inhibition effectively reversed Piezo1 induced defective efferocytosis in BMDMs... We reveal a novel role of Piezo1 in the insufficient macrophage efferocytosis during MI and identified the Ca2+/ATF4/SLC7A11 mediates the Piezo1 induced impaired macrophage efferocytosis."
Cardiovascular • Inflammation • Myocardial Infarction • ATF4 • SLC7A11
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Lu Peng2; yongzhen Guo2; xue han2; Shiyue Wang2; Zhaoyi Luo2; Yunlong Xia2; huilan Tan1; Xiaoming Xu2; quanchi liu2; Fengyue Ding2; Huishou Zhao2; Yajing Wang1; Ling Tao2; Wenjun Yan2
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