MIR-122 DELIVERED BY HEPATOCYTE EXTRACELLULAR VESICLES PROMOTES FERROPTOSIS IN HEPATIC STELLATE CELLS (AASLD 2024) - Oct 15, 2024 - Abstract #2304; "LX2 HSC were incubated with AML-12 EVs for 48 h and with erastin for the last 24 h prior to measuring viability with AlamarBlue... Hepatocyte EVs potentiate HSC ferroptosis by delivering miR-122, which leads to elevated cellular ferrous iron level and reduction of GPX4 expression possibly by directly repressing GRP78 expression."
GPX4 • HSPA5 • MIR122
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Xinlei Li1; Sherri Kemper1; David Brigstock1
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