Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT. (PubMed, Adv Sci (Weinh)) - Oct 11, 2024 - "In vivo, USP52 depletion combined with ferroptosis triggers imidazole ketone Erastin (IKE) synergistically restrains BLCA progression by inducing ferroptosis. These findings elucidate the role of the USP52-xCT axis in BLCA and highlight the therapeutic potential of targeting USP52 and ferroptosis inducers in BLCA."
Journal • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • SLC7A11
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Fenfang Zhou; Gang Wang; Houyi Wei; Jianmin Liu; Jingtian Yu; Kaiyu Qian; Lingao Ju; Mingxing Li; Renjie Zhang; Siming Chen; Wan Jin; Wenyu Jiang; Xinghuan Wang; Yejinpeng Wang; Yi Zhang; Yongwen Luo; Yu Xiao
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