Cytoglobin attenuates melanoma malignancy but protects melanoma cells from ferroptosis. (PubMed, Mol Med Rep) - Oct 7, 2024 - "It was observed that B16F10 and A375 melanoma cells with loss of CYGB expression were highly sensitive to ferroptosis inducers RSL3 and erastin, whereas G361 melanoma cells with highly enriched CYGB were resistant to RSL3 or erastin. In vivo study also demonstrated that CYGB overexpression rendered xenograft melanoma much more resist to RSL3 treatment. Based on these findings, CYGB is a potential therapeutic biomarker to screen the melanoma patients who are most likely benefit from ferroptosis treatment."
Journal • Genetic Disorders • Melanoma • Oncology • Skin Cancer • Solid Tumor • GPX4
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Feng Wang; Jinjie Zhang; Pan Zhu; Qingyao Yu; Xiaohong Zhang; Yong Yang; Zuquan Zou
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