Mild therapeutic hypothermic protection activates the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by myocardial ischemia‑reperfusion injury. (PubMed, Mol Med Rep) - Oct 4, 2024 - "Treatment with 2‑aminoethoxydiphenyl borate (an inhibitor of TRPM7) could further strengthen the myocardial protective effects of MTH, whereas treatment with erastin (promoter of ferroptosis) and wortmannin (inhibitor of PI3K) led to the effective elimination of the myocardial protective effects of MTH. Compared with in the I/R group, the PI3K/AKT activation level and the expression levels of GPX4 were both significantly increased, whereas the expression levels of TRPM7 and ACSL4 were significantly decreased in the I/R + MTH group. Taken together, the results of the present study indicated that MTH may activate the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by MIRI."
Journal • Cardiovascular • Myocardial Infarction • Myocardial Ischemia • Reperfusion Injury • ACSL4 • ANXA5 • GPX4 • TRPM7
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Deju Zhang; Fan Xiao; Jing Zhang; Peng Yu; Shuchun Yu; Wei Deng; Xiaoyi Tang; Yang Liu; Yaqi Li; Yixuan Chen; Zhaoying Tan; Zicheng Zhu
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