Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

sirolimus - Generic mfg.

dorsomorphin (Compound C) - EMD Serono

Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1. (PubMed, Int J Mol Med) - Oct 4, 2024 - "However, erastin (a ferroptosis activator), pAD/HES1‑short hairpin RNA, rapamycin (an autophagy activator) and Compound C (an AMPK inhibitor) blocked the protective effect of Cur. In conclusion, Cur pretreatment inhibited ferroptosis, autophagy overactivation and oxidative stress; improved mitochondrial dysfunction; maintained energy homeostasis; attenuated apoptosis; and ultimately protected the myocardium from A/R injury via increased HES1 expression."
Journal • Cardiovascular • Metabolic Disorders • Myocardial Infarction • Myocardial Ischemia • Reperfusion Injury • BCL2 • CASP3 • GPX4 • HES1 • PTGS2

http://www.ncbi.nlm.nih.gov/pubmed/39364745

Chenchao Zou; Huang Huang; Jichun Liu; Ming Fang; Songqing Lai; Tie Hu; Yamei Qiao; Yong Yuan

Oct 4, 2024