IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH RESISTANCE TO CDDP AND FERROPTOSIS/CUPROPTOSIS INDUCERS IN OVARIAN CANCER USING GENOME-SCALE CRISPR/CAS9 KNOCKOUT TECHNOLOGY AND AI VIRTUAL SCREENING (IGCS 2024) - Oct 4, 2024 - Abstract #EV342 / #765; "This study focuses on identifying genetic determinants of resistance to cisplatin (CDDP) and novel cell death pathways, such as ferroptosis and cuproptosis, induced by erastin and a combination of disulfiram and copper (ES+Cu), respectively. Our preliminary findings have identified several key genes implicated in resistance mechanisms specific to the drug treatments used. Notably, genes involved in iron and copper metabolism pathways were highlighted as crucial in the context of ferroptosis and cuproptosis resistance. AI-driven analysis further pinpointed several compounds with high binding affinities to these targets, suggesting their potential for reversing resistance."
Biomarker • Oncology • Ovarian Cancer • Solid Tumor
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