Imperatorin ameliorates ferroptotic cell death, inflammation, and renal fibrosis in a unilateral ureteral obstruction mouse model. (PubMed, Phytomedicine) - Sep 29, 2024 - "Our finding demonstrated for the first time, that imperatorin treatment holds therapeutic potential in a UUO mouse model of CKD and inhibits the erastin-induced oxidative stress, ferroptosis, and subsequent lipid peroxidation in vitro. This highlights the potential of imperatorin as a future therapeutic target for ferroptosis to improve the progression of CKD."
Journal • Preclinical • Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • Nephrology • Oncology • Renal Disease • CAT • GPX4 • NOX4 • SLC7A11 • SOD2
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Chang Mu Chen; Cheng Tien Wu; Chun Fa Huang; Haw Ling Chuang; Huey Liang Kuo; Jr-Di Yang; Kuan-I Lee; Pei Yu Weng; Pei Yun Wang; Po Lin Liao; Shing-Hwa Liu; Siao Syun Guan; Ssu Chia Lin; Yen Hao Su; Yu Syuan Chen
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